An efficient synthesis of α-acyloxyketone by Cu(acac)2-catalyzed insertion reaction of α-diazoketone to carboxylic acid

Article abstract of DOI:10.1016/S0040-4039(98)00578-4

An efficient insertion reaction of α-diazoketone to various carboxylic acids was achieved by using Cu(acac)₂ as a catalyst. Treatment of the diazo compound with a carboxylic acid (1.2 equiv) in the presence of Cu(acac)₂ (0.1 equiv) at room temperature afforded the corresponding ketoester in good yield. Various kinds of functional groups were tolerated under the reaction conditions.