Bioorganic and Medicinal Chemistry Letters p. 2347 - 2350 (2007)
Update date:2022-08-05
Topics:
Li, Jianke
Wakefield, Brian D.
Ruble, J. Craig
Stiff, Cory M.
Romero, Donna L.
Marotti, Keith R.
Sweeney, Michael T.
Zurenko, Gary E.
Rohrer, Douglas C.
Thorarensen, Atli
Discovery of novel antibacterial agents is a significant challenge. We have recently reported on our discovery of novel antibacterial agents in which we have rapidly optimized potency utilizing a parallel chemistry approach. These advanced leads suffer from high affinity for human serum albumin (HSA). In an effort to decrease the affinity for HSA we have prepared a series of heterocyclic analogs, which retained antibacterial activity and demonstrated reduced affinity for HSA.
View MoreContact:+86-22-83718541
Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Xiamen Hisunny Chemical Co.,Ltd
website:http://www.hisunnychem.com
Contact:+86-592-3327115
Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China
Chongqing KonAo Health Co.,Ltd
Contact:13687578375
Address:wuhan hubei china
Luzhou North Chemical Co., Ltd.
Contact:+86-830-2796784;+86-830-2796776
Address:Gaoba, Longmatan District, Luzhou, Sichuan Province
website:http://www.dulynet.com/
Contact:025-84699383 -8003
Address:Room 503, Building 2, Chuangxinhui, No. 61 Wenjing Road, High-tech Development Zone, Pukou District, Nanjing City, Jiangsu Province Nanjing, Jiangsu
Doi:10.1016/S0020-1693(00)87247-3
(1978)Doi:10.1016/S0031-9422(00)90411-4
(1994)Doi:10.1021/ja01168a527
(1950)Doi:10.1002/oms.1210130105
(1978)Doi:10.1016/S0031-9422(00)97688-X
(1983)Doi:10.1021/ja01878a047
(1939)