Bioorganic and Medicinal Chemistry Letters p. 2330 - 2334 (2011)
Update date:2022-08-04
Topics:
Hong, Qingmei
Bakshi, Raman K.
Palucki, Brenda L.
Park, Min K.
Ye, Zhixiong
He, Shuwen
Pollard, Patrick G.
Sebhat, Iyassu K.
Liu, Jian
Guo, Liangqin
Cashen, Doreen E.
Martin, William J.
Weinberg, David H.
MacNeil, Tanya
Tang, Rui
Tamvakopoulos, Constantin
Peng, Qianping
Miller, Randy R.
Stearns, Ralph A.
Chen, Howard Y.
Chen, Airu S.
Strack, Alison M.
Fong, Tung M.
MacIntyre, D. Euan
Wyvratt, Matthew J.
Nargund, Ravi P.
We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.
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