Synthesis and Evaluation as Glycosidase Inhibitors of Isoquinuclidines Mimicking a Distorted β-Mannopyranoside

DOI: 10.1002/hlca.200390320

Source and publish data:

Helvetica Chimica Acta p. 3787 - 3817 (2003)

Update date:2022-08-04

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Authors:

Boehm, Matthias

Lorthiois, Edwige

Meyyappan, Muthuppalaniappan

Vasella, Andrea

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Article abstract of DOI:10.1002/hlca.200390320

Racemic and enantiomerically pure manno-configured isoquinuclidines were synthesized and tested as glycosidase inhibitors. The racemic key isoquinuclidine intermediate was prepared in high yield by a cycloaddition (tandem Michael addition/aldolisation) of

Full text of DOI:10.1002/hlca.200390320

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