REGIO AND STEREOSPECIFIC SYNTHESIS OF 11β-SUBSTITUTED 19-NORSTEROIDS. Influence of 11β-substitution on progesterone receptor affinity.

Article abstract of DOI:10.1016/0039-128X(81)90039-8

The convenient synthesis of a series of 11β-substituted 17-ethynyl-17β-hydroxy-4,9-estradien-3-ones and their corresponding estradiols is reported.Relative affinities for the progestin and estrogen receptors showed very specific interactions between the p