Pharmacology on rat ileum of certain 2-substituted 3-(dimethylamino)-5,6-dimethoxyindenes related to 5,6-(methylenedioxy)indene calcium antagonists

Article abstract of DOI:10.1021/jm00210a028

Whereas the 2-propyl- and 2-butyl-5,6-(methylenedioxy)indene caclium antagonists reversed the spasmogenic action of several agonists including PGF(2α) and acetylcholine at 5 x 10^-5 to 10^-4 M on the rat ileum, the corresponding 5,6-dimethoxy analogues exhibited spasmogenic activity at higher concentration (10^-4-10^-3 M) and exhibited neither spasmogeric nor spasmolytic activity at lower (10^-6-10^-5 M) concentration. The results are compared to the methyl and 2-ethyl analogues. At 10^-4 M only the butyl analogue was capable of moderate antagonism of acetylcholine and at 10^-3 M all four analogues were capable of moderately antagonizing the actions of acetylcholine.