Journal of Medicinal Chemistry p. 1313 - 1315 (1978)
Update date:2022-08-04
Topics:
Witiak
Kakodkar
Brunst
Baldwin
Rahwan
Whereas the 2-propyl- and 2-butyl-5,6-(methylenedioxy)indene caclium antagonists reversed the spasmogenic action of several agonists including PGF(2α) and acetylcholine at 5 x 10-5 to 10-4 M on the rat ileum, the corresponding 5,6-dimethoxy analogues exhibited spasmogenic activity at higher concentration (10-4-10-3 M) and exhibited neither spasmogeric nor spasmolytic activity at lower (10-6-10-5 M) concentration. The results are compared to the methyl and 2-ethyl analogues. At 10-4 M only the butyl analogue was capable of moderate antagonism of acetylcholine and at 10-3 M all four analogues were capable of moderately antagonizing the actions of acetylcholine.
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Doi:10.1021/ol0497685
(2004)Doi:10.1016/S0960-894X(01)00770-3
(2002)Doi:10.1021/ja00492a028
(1978)Doi:10.1021/jo01321a025
(1979)Doi:10.1016/S0022-328X(00)99501-9
(1983)Doi:10.1021/ic0493954
(2004)
