The Knoevenagel Reactions of Aldehydes with Carboxy Compounds. I. Reactions of p-Nitrobenzaldehyde with Active Methine Compounds

Article abstract of DOI:10.1246/bcsj.61.2473

The Knoenvenagel reactions of p-nitrobenzaldehyde (1) with β-keto acids, methylmalonic (2a) and α-methylacetoacetic acids (2b) were carried out in the presence of a tertiary amine such as pyridine.We have isolated the corresponding β-hydroxy intermediate