Journal of the Chemical Society. Perkin transactions I p. 2451 - 2455 (1981)
Update date:2022-08-05
Topics:
Reese, Colin B.
Titmas, Richard C.
Valente, Lydia
When 5'-O-methoxytetrahydropyranylthymidylyl-(3' -> 5')-3'-O-methoxytetrahydropyranylthymidine o-chlorophenyl ester (12) is treated with an excess of toluene-p-thiol and triethylamine in acetonitrile solution at room temperature, it is cleaved to give 5'-O-methoxytetrahydropyranylthymidine 3'-(o-chlorophenyl) phosphate (10) and 5'-deoxy-5'-(p-tolylthio)-3'-O-methoxytetrahydropyranylthymidine (13).The bearing of this result on the synthesis of oligonucleotides by the phosphotriester approach is discussed.
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Doi:10.1002/hlca.19780610737
(1978)Doi:10.1021/jm00230a001
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(1978)
