Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors

DOI: 10.1016/j.bmcl.2020.127472

Source and publish data:

Bioorganic and Medicinal Chemistry Letters (2020)

Update date:2022-08-05

Topics: Mechanism of Action Structure-Activity Relationship (SAR) Antiviral Activity Publication and Patents Compound Structure In Vitro and In Vivo Studies

Authors:

Jang, Min Seong

Jin, Young-hee

Kim, Hyoung Rae

Kim, Seungtaek

Kwon, Sunoh

Lee, Jihye

Lee, Jun Young

Park, Chul Min

Shin, Young Sup

Song, Jong Hwan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmcl.2020.127472

New therapies for treating coronaviruses are urgently needed. A series of 4-anilino-6-aminoquinazoline derivatives were synthesized and evaluated to show high anti-MERS-CoV activities. N⁴-(3-Chloro-4-fluorophenyl)-N⁶-(3-methoxybenzyl

Full text of DOI:10.1016/j.bmcl.2020.127472

Products guided by the article

Product name:N-(3-methoxyphenyl)-6-nitroquinazolin-4-amine

Cas No:691385-34-9

R&D Labs maybe for 691385-34-9

Winchem Industrial Co. Ltd.(expird)

Contact:86-574-83851061 86-574-87083208

Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China
Du-Hope International Group

website:http://www.np-chem.com

Contact:0086-25-52346877

Address:199, Jian Ye Road, Nanjing, China
Shanghai Longjin Metallic Material Co., Ltd.

website:http://www.shlongjin.cn/

Contact:021-56517503,56502257

Address:No.16, Lane 555, Chengyin Road, Shanghai
Eastar Chemical Corporation

website:http://www.eastarchem.com/

Contact:1-800-898-2436

Address:1215 K Street, STE 1700
Shandong Xingshun New Material Co., Ltd.

website:http://www.sd-xingshun.com

Contact:+86-519-86461196/+86-519-86464994

Address:Middle of Luhua East Road, Dingtao District

Relevant to this article

RCM-mediated synthesis of trifluoromethyl-containing nitrogen heterocycles

Doi:10.1021/jo060893z
(2006)
Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators

Doi:10.1016/j.bioorg.2020.104614
(2021)
Synthesis of Dimeric ADP-Ribose and Its Structure with Human Poly(ADP-ribose) Glycohydrolase

Doi:10.1021/ja512528p
(2015)
Formation of neutral and cationic methyl derivatives of titanium containing cyclopentadienyl and aryloxide ancillary ligation

Doi:10.1021/om0341404
(2004)
Copper-amine-carbonyl chemistry. Solution and solid-state studies of the copper(I)-ethylenediamine-carbon monoxide system: Synthesis and X-ray structures of mononuclear and binuclear copper(I)-carbonyl complexes

Doi:10.1021/ic50207a016
(1980)
Boron nitride as an alternative support of Pd catalysts for the selective oxidation of lactose

Doi:10.1016/j.catcom.2012.10.007
(2012)

Article Doi