SYNTHESIS OF 1H-IMIDAZOQUINOLIN-4(5H)-ONE VIA PALLADIUM-CATALYZED CYCLIZATION OF N-(2-BROMOPHENYL)-1H-IMIDAZOLE-4-CARBOXAMIDE

Article abstract of DOI:10.1016/0040-4039(91)80443-A

A new heterocycle, 5-butyl-1-methyl-1H-imidazole<4,5-c>quinolin-4(5H)-one has been synthesized using palladium-catalyzed cyclization.A yield of the cyclization was optimized by changing base, additive and reaction temperature.