Quantitative structure-activity relationships in 2,5-bis(1-aziridinyl)-p-benzoquinone derivatives against leukemia L-1210

Article abstract of DOI:10.1021/jm00191a006

Antileukemic activities of more than 30 2,5-bis(1-aziridinyl)-p-benzoquinones were correlated against well-defined physicochemical constants. These compounds were evaluated against lymphoid leukemia L-1210 in BDF₁ mice. The best equations obtai