Composition of iodopropylideneglycerol: An example of the application of 2D NMR spectroscopy to structure elucidation

Article abstract of DOI:10.1002/(SICI)1097-458X(199606)34:6<434::AID-OMR897>3.0.CO;2-O

Using 1D and 2D NMR spectra, the compounds obtained, in a mixture, in the reaction of glycerol with iodine were identified as the two isomers (cis and trans) of 2-iodomethyl-5-hydroxymethyl-1,4-dioxane and the two isomers (cis and trans) of 2-iodomethyl-6-hydroxymethyl-1,4-dioxane. Thus, the composition of the pharmaceutical formulation named IPG has finally been established.