A formal total synthesis of (±)-anatoxin-a by an intramolecular Pd- catalyzed aminocarbonylation reaction

Article abstract of DOI:10.1016/S0040-4039(98)00078-1

9-Azabicyclo[4.2.1]nonane skeleton 3a was prepared by intramolecular aminocarbonylation of 2a catalyzed by palladium. In three steps 3a was transformed into 8 which had previously been transformed into anatoxin-a, thus completing the formal total synthesis.