Organic Letters p. 6414 - 6419 (2020)
Update date:2022-08-05
Topics:
Cao, Hao-Qiang
Liu, Hao-Nan
Liu, Zhe-Yuan
Qiao, Baokun
Zhang, Fa-Guang
Ma, Jun-An
A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted α,β-dehydro α-amino carboxylic esters and H-phosphites is described. This C(sp2)-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted β-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.
View MoreContact:86-21-57725962
Address:shanghai
Wuhan Sunrise Pharmaceutical Technology Co., Ltd
Contact:+86-27-83314682
Address:Room 340, New material Industrial base No.17, Gu Tian Five Lu , Qiaokou District, Wuhan , China
website:http://www.hope-chem.com
Contact:86-21-58090396-805
Address:Floor 4, Building 5, No.588 Tianxiong Road, Zhoupu International Medical Zone, ShangHai, China
ShanDong XinDa Chemical CO.,LTD(expird)
Contact:086-0311-87580543
Address:No.168, High Technology Development Zone Jinan Shandong China
website:http://www.fwdchem.com
Contact:86-21-54450828
Address:Room 802,Lotus Tower ,159 Tianzhou Road,Xuhui District,Shanghai
Doi:10.1016/j.bmc.2003.10.048
(2004)Doi:10.1016/S0040-4039(01)93528-2
(1979)Doi:10.3184/174751912X13397801313284
(2012)Doi:10.1007/BF00471769
()Doi:10.1021/jm00398a006
(1988)Doi:10.1021/acs.joc.8b02278
(2018)
