Journal of the Chemical Society. Perkin transactions I p. 1269 - 1276 (1996)
Update date:2022-07-30
Topics:
Bull, James R.
Loedolff, Michiel C.
Conjugate alkylation of 3-methoxyestra-1,3,5(10),15-tetraen-17-one 1 leads to 15β-alkyl 17-ketones 2 (Me, Et or Pri), which are converted, via palladium acetate-mediated dehydrosilylation of their derived silyl enol ethers, into the corresponding 15-alkyl Δ15-17-ketones 5. Conjugate alkylation of these intermediates results in formation of 15,15-dialkyl 17-ketones 10, which undergo stereoselective reduction with lithium aluminium hydride, and deprotection of C-3 to give 15,15-dialkyl analogues 12 of estradiol. Spectroscopic data are presented to demonstrate that substrates 1 and 5 undergo exclusive 15β-alkylation.
View MoreNantong LiKai Chemical Co.,Ltd
Contact:+86-513-89068669
Address:Jincheng Science Park
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD
Contact:+86-755-82412922
Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
guide(suzhou) fine materials co. ltd
Contact:0512-80972173
Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
Wuhan Konberd Biotech Co., Ltd.
Contact:+86-27-87205925
Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Contact:+852-8198 2399
Address:9E, Leapont Industrial Building, 18-28 Wo Liu Hang Road, Shatin, New Territories, Hong Kong
Doi:10.1016/0009-3084(94)90109-0
(1994)Doi:10.1246/bcsj.52.1115
(1979)Doi:10.1016/j.poly.2004.03.001
(2004)Doi:10.1039/c39790000663
(1979)Doi:10.1002/ardp.19793120605
(1979)Doi:10.1021/ja01331a029
(1933)
