2,2'-bis(aminomethyl)-4,4'-bithiazole as a new Cu(II)-dependent DNA cleaving agent

DOI: 10.1248/cpb.44.1761

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1761 - 1764 (1996)

Update date:2022-07-29

Topics:

Authors:

Sasaki, Hideaki

Takanori, So-Ichi

Yamamoto, Keisuke

Nakamoto, Yasuyuki

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Article abstract of DOI:10.1248/cpb.44.1761

A simple and readily available DNA cleaving agent, 2,2'- bis(aminomethyl)-4,4'-bithiazole at 50 μM concentration showed a significant cleaving activity for plasmid DNA only in the presence of Cu(II) under physiological conditions without any reducing agents.

Full text of DOI:10.1248/cpb.44.1761

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