Journal of Pharmaceutical Sciences p. 220 - 223 (1985)
Update date:2022-08-02
Topics:
Yarwood
Moore
Collett
An accurate, reproducible, and specific reversed-phase high-performance liquid chromatographic (HPLC) system was developed for the determination of ethacrynic acid and its degradation products. The method was used in stability studies of the drug in the solid state, in solution, and in dosage forms. Three degradation products were isolated by preparative chromatography and identified by several techniques, principally NMR and MS. TLC R(f) and HPLC response factors are quoted. A degradation scheme consistent with the observed stability profiles is proposed.
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Doi:10.1021/om0201359
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(2002)
