Journal of Pharmaceutical Sciences p. 220 - 223 (1985)
Update date:2022-08-02
Topics:
Yarwood
Moore
Collett
An accurate, reproducible, and specific reversed-phase high-performance liquid chromatographic (HPLC) system was developed for the determination of ethacrynic acid and its degradation products. The method was used in stability studies of the drug in the solid state, in solution, and in dosage forms. Three degradation products were isolated by preparative chromatography and identified by several techniques, principally NMR and MS. TLC R(f) and HPLC response factors are quoted. A degradation scheme consistent with the observed stability profiles is proposed.
View MoreReliable Pharma Technology (Shanghai) Co., Ltd.
Contact:0086-21-67676847-8008
Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.
Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Contact:86-180510-83338
Address:Suite# 210, No. 1 BuildingNanjing Agricultural Biotechnology High-tech Entrepreneurship Center, No. 4 Tongwei Road, Xuanwu District, Nanjing,China
Contact:+86 18616952870
Address:Area
Jinan Decheng Hemu Medical Technology Co.，Ltd.
Contact:+86-531-68650525
Address:NO.554 Zhengfeng Road High-new Technology Development Zone
Suzhou Time-chem Technologies Co., Ltd.
Contact:0512-63983931/68086856
Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
Doi:10.1021/om0201359
(2002)Doi:10.1021/ja01874a010
(1939)Doi:10.1016/S0040-4039(02)00572-5
(2002)Doi:10.1016/S0040-4039(01)01222-9
(2001)Doi:10.1080/00397910500297297
(2005)Doi:10.1016/S0040-4039(02)00136-3
(2002)
