Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor

DOI: 10.1021/jacs.7b02985

Source and publish data:

Journal of the American Chemical Society p. 7052 - 7061 (2017)

Update date:2022-08-05

Topics:

Authors:

Kornahrens, Anne F.

Cognetta, Armand B.

Brody, Daniel M.

Matthews, Megan L.

Cravatt, Benjamin F.

Boger, Dale L.

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Article abstract of DOI:10.1021/jacs.7b02985

The design and examination of 4,1,2-benzoxathiazin-3-one 1,1-dioxides as candidate serine hydrolase inhibitors are disclosed, and represent the synthesis and study of a previously unexplored heterocycle. This new class of activated cyclic carbamates provi

Full text of DOI:10.1021/jacs.7b02985

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