Chemistry - A European Journal p. 2529 - 2547 (2004)
Update date:2022-08-05
Topics:
Storer, R. Ian
Takemoto, Toshiyasu
Jackson, Philip S.
Brown, Dearg S.
Baxendale, Ian R.
Ley, Steven V.
The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.
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