Synthesis and Anticancer Activity of Nitrosourea Derivatives of Phensuximide

DOI: 10.1021/jm00177a024

Source and publish data:

Journal of Medicinal Chemistry p. 324 - 326 (1980)

Update date:2022-07-30

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Authors:

Crider, A. Michael

Kolczynski, Thomas M.

Yates, Kathleen M.

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Article abstract of DOI:10.1021/jm00177a024

Nitrosourea derivatives 9-13 which utilize phensuximide (1) as the carrier were synthesized as potential central nervous system antitumor agents.The N-(2-chloroethyl)-N-nitrosourea 13 was active in the mouse ependymoblastoma brain-tumor system, as well as

Full text of DOI:10.1021/jm00177a024

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