Journal of Medicinal Chemistry p. 335 - 338 (1980)
Update date:2022-08-05
Topics:
Pfister, Juerg R.
Wymann, Walter E.
Schuler, Margery E.
Roszkowski, Adolph P.
Twenty-five flavone-6-carboxylic acids were synthesized and tested as to their ability to inhibit histamine-induced gastric acid secretion in the rat. 3-Isopropoxy-4'-methoxyflavone-6-carboxylic acid (41) showed consistent oral activity while being devoid of any other noteworthy pharmacological effects.In vitro, this compound was found to be inactive as a histamine H2 antagonist, and its mode of action remains unknown.
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(1980)
