One-step Synthesis of Functionalized Dioxaspirodecanes from β-Phenylsulfonyl Dihydrofurans and γ-Lactones

Article abstract of DOI:10.1016/0040-4039(94)85041-0

A one-step synthesis of differently substituted 1,6-dioxaspiro<4,5>decanes from readily available starting materials is described.The process is based on the condensation of the α-anion derived from β-phenylsulfonyl dihydrofurans with γ-lactones.The spirocyclization occurs with high stereoselectivity at C-4, C-5 and C-9, but not at C-2.