Synthesis of potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase for testing as antiprotozoal agents. I. 7-Substituted 6-oxopurines

DOI: 10.1021/jm00178a002

Source and publish data:

Journal of Medicinal Chemistry p. 357 - 364 (1980)

Update date:2022-08-05

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Authors:

Piper Piper

Laseter Laseter

Montgomery

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Article abstract of DOI:10.1021/jm00178a002

Biological evidence indicates that the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) (EC 2.4.2.8) is vital for cell proliferation in malarial parasites but nonessential for mammalian cells. 7-Substituted guanines and hypoxanthines in wh

Full text of DOI:10.1021/jm00178a002

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