Synthesis and monoamine oxidase inhibitory activities of α-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes

Article abstract of DOI:10.1021/jm00361a017

A series of 15 α-allenic amines, including primary, secondary, and tertiary ones, was synthesized, partly by organocopper chemistry. Their ability to inhibit mouse and rat brain mitochondrial monoamine oxidase (MAO) in vivo and in vitro, respectively, was