Journal of Organic Chemistry p. 2548 - 2550 (1980)
Update date:2022-08-05
Topics:
Kozikowski, Alan P.
Ames, Anthony
A conceptually new route to the benzylisoquinoline alkaloids has been devised.The reaction of 2-lithiooxazoles with aromatic aldehydes to generate the thermodynamically favored 2-substituted oxazoles constitutes the key step in this process.A single-pot two carbon-carbon bond-joining reaction leading to an oxazoline suitable for further transformation to a phenethylamide is also described.
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Doi:10.1021/jm9811209
(1999)Doi:10.1021/jm00180a009
(1980)Doi:10.1016/S0040-4039(99)02053-5
()Doi:10.1248/cpb.27.3101
(1979)Doi:10.1071/CH9792473
(1979)Doi:10.1007/BF00579419
(1982)
