Journal of Organic Chemistry p. 3108 - 3111 (1980)
Update date:2022-08-03
Topics:
Vaughan, John D.
Vaughan, Virginia L.
Daly, Steven S.
Smith, William A.
Since the rate law for the diiodination of imidazole provides information on the iodination of C4(5) but not C2 in the imidazole ring, we have investigated the kinetics of iodination of the two positions separately in 2-methylimidazole and 4-methylimidazole, respectively.The observed rate laws for the methylimidazoles exhibited hydrogen ion dependencies that differed from that of imidazole; the iodinations of all three substrates were base catalyzed, but like imidazole, 2-methylimidazole undergoes uncatalyzed iodination, while 4-methylimidazole does not.The overall rate of iodination of 4-methylimidazole was faster than that of 2-methylimidazole which was faster than that of imidazole.
View MoreContact:86-28-61993785
Address:No.70-13-21, North Section, Erhuan
Contact:732.938.2777
Address:5012 Industrial Road Farmingdale, NJ 07727
TIANJIN NORTH JINHENG CHEMICAL PLANT.
Contact:0086-22-59952083
Address:DongShigu Country In JiXian TianJin China
Hangzhou Deli Chemical Co.,Ltd.
website:http://www.dlchemical.com
Contact:86 571 28006267
Address:Tangxi Industrial Area, Yuhang District, Hangzhou
Contact:+86 21 5017 5386
Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
Doi:10.1021/jo00260a025
(1988)Doi:10.1021/acs.orglett.7b01215
(2017)Doi:10.1080/17415993.2014.933341
(2014)Doi:10.1246/bcsj.53.179
(1980)Doi:10.1007/BF00903239
(1980)Doi:10.1016/S0040-4020(01)80708-0
(1994)