Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin

DOI: 10.1016/j.bmcl.2004.05.017

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3687 - 3689 (2004)

Update date:2022-08-04

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Authors:

Chandrasekhar

Jagadeshwar

Narsihmulu, Ch.

Sarangapani

Krishna Krishna

Vidyasagar

Vijay, Dolly

Sastry, G. Narahari

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Article abstract of DOI:10.1016/j.bmcl.2004.05.017

A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of β-tubulin.

Full text of DOI:10.1016/j.bmcl.2004.05.017

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