Inhibitors of Sterol Biosynthesis. Synthesis of 9α-Fluoro-3β-hydroxy-5α-cholest-8(14)-en-15-one and Related Compounds

DOI: 10.1021/jo01308a018

Source and publish data:

Journal of Organic Chemistry p. 4034 - 4037 (1980)

Update date:2022-08-04

Topics:

Authors:

Parish, Edward J.

Schroepfer, George J.

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Article abstract of DOI:10.1021/jo01308a018

9α-Fluoro-3β-hydroxy-5α-cholest-8(14)-en-15-one has been prepared in 90percent yield by treatment of 3β,9α-dihydroxy-5α-cholest-8(14)-en-15-one with HF-pyridine.These two compounds are potent inhibitors of sterol biosynthesis in animal cells in culture an

Full text of DOI:10.1021/jo01308a018

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Product name:3β-(Benzoyloxy)-15-ethoxy-5α-cholesta-8,14-diene

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CHINA MEHECO CORPORATION

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Chengdu Push Bio-technology Co., Ltd

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SHAANXI TOP PHARM CHEMICAL CO.LTD

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