Synlett p. 193 - 194 (1997)
Update date:2022-08-05
Topics:
Mahler, Mikael E.
Palmer, Michael J.
The novel trans-3-oxabicyclo[3,3.0]octan-7-one system has been prepared by intramolecular ring closure of the corresponding cyclopentane diol. Peralkylation and benzylidene substitution of the octanone has allowed the preparation of tetra-alkylated potential inhibitors of HIV protease. Weak activity against HIV protease (IC50's 70-100μM) was observed.
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