Journal of Medicinal Chemistry p. 1136 - 1139 (1980)
Update date:2022-08-05
Topics: NMR spectra Elemental analyses Derivatives Thin-layer chromatography Biological testing Purification and characterization Structure-Activity Relationship (SAR) Studies Deprotection (if applicable)
Piper, James R.
Laseter, Anne G.
Johnston, Thomas P.
Montgomery, John A.
Evidence indicating that effective in vivo inibition of hypoxanthine-guanine phosphoribosyltransferase (HGPRT, EC 2.4.2.8) should produce antiprotozoal activity without significant toxic effects on mammalian hosts prompted syntheses of 1-substituted hypox
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