
Tetrahedron Letters p. 857 - 858 (1991)
Update date:2022-09-26
Topics:
Burke, Steven D.
Piscopio, Anthony D.
Marron, Brian E.
Matulenko, Mark A.
Pan, Gonghua
The presence of a removable 1-(trimethylsilyl) residue greatly increases the chelation-controlled diastereoselectivity in alkenylcuprate additions to chiral β-alkoxyaldehydes.Several methods for protiodesilylation of the resultant allylic alcohols <5 -> 2b (R=Me3SiCH2CH2OCH2-, PhCH2OCH2-, and PhCH2-)> are compared.
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