Enantioselective synthesis of 2,3-disubstituted piperidines from (S)- methylpyroglutamate

Article abstract of DOI:10.1016/S0040-4039(98)02190-X

N-methoxy-N-methylamide derived from (S)-methylpyroglutamate was prepared in good yield and allowed the addition of Grignard reagents. Erythro (2S)-1-benzyl-2-hydroxybenzyl pyrrolidine obtained by this way was converted into (2S,3R)-1-benzyl-3-hydroxy-2-phenylpiperidine and its chloro analog.