Tetrahedron Letters p. 9447 - 9450 (1998)
Update date:2022-08-02
Topics:
Calvez, Olivier
Chiaroni, Angele
Langlois, Nicole
N-methoxy-N-methylamide derived from (S)-methylpyroglutamate was prepared in good yield and allowed the addition of Grignard reagents. Erythro (2S)-1-benzyl-2-hydroxybenzyl pyrrolidine obtained by this way was converted into (2S,3R)-1-benzyl-3-hydroxy-2-phenylpiperidine and its chloro analog.
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