Synthesis, enzymic degradation, lipophilic properties, and biological activity of [D-alanine2, t-butylglycine 5]enkephalin amide

DOI: 10.1002/hlca.19800630410

Source and publish data:

Helvetica Chimica Acta p. 824 - 831 (1980)

Update date:2022-07-30

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Authors:

Fauchere

Petermann

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Article abstract of DOI:10.1002/hlca.19800630410

L-C(a)-t-Butylglycine (Bug), its amide, methyl ester, and N(a)-t-butoxycarbonyl derivative were prepared by an asymmetric synthesis, and the Hansch side-chain hydrophobic (lipophilicity) parameter determined. A new enkephalin analogue, H . Tyr-D-Ala-Gly-Phe-Bug . HN₂ was synthesized which is pharmacologically active in two in vitro assays and strongly resistant against a number of enzymes in vitro.

Full text of DOI:10.1002/hlca.19800630410

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