Antihypertensive (2-Aminoethyl)thiourea Derivatives. 1

DOI: 10.1021/jm00186a019

Source and publish data:

Journal of Medicinal Chemistry p. 1387 - 1392 (1980)

Update date:2022-08-04

Topics:

Authors:

Tilley. Jefferson W.

Levitan, Paul

Kierstead, Richard W.

Cohen, Michael

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00186a019

Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas.From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog.In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.

Full text of DOI:10.1021/jm00186a019

Products guided by the article

Product name:b-Alanine, N-[[(2,6-dichlorophenyl)amino]thioxomethyl]-

Cas No:75257-71-5

R&D Labs maybe for 75257-71-5

Jinzhou Jiutai Pharmaceutical Co.,Ltd

Contact:+86-0416-5179890

Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
Anhui Eapearl Chemical Co., Ltd.

Contact:86-562-5858458

Address:358 South Huaihe Road
Nantong Kaixin Pharma Chemical Co.,Ltd.

Contact:86-513-85250786

Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
Pengchen New Material Technology Co., Ltd.

Contact:+86-512-63680537

Address:99.6 km of national road 318, Meiyan Community,Pingwang Town, Wujiang District, Suzhou 215225
Shijiazhuang Sdyano Fine Chemical Co., Ltd

Contact:+86-311-89830448

Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China

Relevant to this article

Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors

Doi:10.1016/j.bmcl.2004.05.090
(2004)
Cob(I)alamin als Katalysator. 6. Mitteilung <1>. Bildung und Fragmentierung von Alkylcobalaminen, ein Gleichgewichtsprozess zwischen nukleophiler Addition und reduktiver Fragmentierung

Doi:10.1002/hlca.19800630225
(1980)
Synthesis of (Z)-4-(acylamino)- and 4-(alkylamino)-α-oximinophenylacetic acids: properties and stereochemical determination

Doi:10.1021/jo00314a029
(1981)
Synthesis and Antihypertensive Activity of 1-(2-Thiazolyl)-3,5-disubstituted -2-Pyrazolines

Doi:10.1002/ardp.200300810
(2004)
One-pot, three-component synthesis of linearly substituted homoallylic alcohols via allyl(isopropoxy)dimethylsilane

Doi:10.1021/ol048892l
(2004)
Dianionic and trianionic macrocycles in cobalt N-confused porphyrin complexes

Doi:10.1039/b404261a
(2004)

Article Doi