Journal of Medicinal Chemistry p. 1387 - 1392 (1980)
Update date:2022-08-04
Topics:
Tilley. Jefferson W.
Levitan, Paul
Kierstead, Richard W.
Cohen, Michael
Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas.From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog.In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.
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