Introduction of α-(acyl) methylthiomethyl group into the aromatic ring by Friedel-Crafts reaction

Article abstract of DOI:10.1016/0040-4039(80)80124-9

Friedel-Crafts α-(acyl)methylthiomethylations of aromatic compounds with α-ethoxycarbonyl, -acetyl, -benzoyl, and -cyano-α-(methylthio)methyl chlorides are described. The resulted products are easily converted to acylmethylated aromatics such as phenylacetate and phenylacetone by reductive desulfurization.