Bioorganic and Medicinal Chemistry Letters p. 4191 - 4195 (2004)
Update date:2022-08-04
Topics:
Nazare, Marc
Essrich, Melanie
Will, David W.
Matter, Hans
Ritter, Kurt
Urmann, Matthias
Bauer, Armin
Schreuder, Herman
Dudda, Angela
Czech, Joerg
Lorenz, Martin
Laux, Volker
Wehner, Volkmar
A series of novel, highly potent 2-carboxyindole-based factor Xa inhibitors is described. Structural requirements for neutral ligands, which bind in the S1 pocket of factor Xa were investigated with the 2-carboxyindole scaffold. This privileged fragment assembly approach yielded a set of equipotent, selective inhibitors with structurally diverse neutral P1 substituents.
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