Conformational requirements for histamine H2-receptor inhibitors: A structure-activity study of phenylene analogues related to cimetidine and tiotidine

DOI: 10.1021/jm00356a005

Source and publish data:

Journal of Medicinal Chemistry p. 140 - 144 (1983)

Update date:2022-08-02

Topics:

Authors:

Hoffman Hoffman

Pietruszkiewicz

Habecker

Phillips

Bolhofer

Cragoe Jr.

Torchiana

Lumma Jr.

Baldwin Baldwin

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Article abstract of DOI:10.1021/jm00356a005

Two series of compounds related to cimetidine and tiotidine were synthesized as part of a study to evaluate the importance of conformational parameters in binding at histamine H₂ receptors. The flexible methylthioethyl connecting chain was repl

Full text of DOI:10.1021/jm00356a005

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