Conformational requirements for histamine H2-receptor inhibitors: A structure-activity study of phenylene analogues related to cimetidine and tiotidine

DOI: 10.1021/jm00356a005

Source and publish data:

Journal of Medicinal Chemistry p. 140 - 144 (1983)

Update date:2022-08-02

Topics:

Authors:

Hoffman Hoffman

Pietruszkiewicz

Habecker

Phillips

Bolhofer

Cragoe Jr.

Torchiana

Lumma Jr.

Baldwin Baldwin

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00356a005

Two series of compounds related to cimetidine and tiotidine were synthesized as part of a study to evaluate the importance of conformational parameters in binding at histamine H₂ receptors. The flexible methylthioethyl connecting chain was repl

Full text of DOI:10.1021/jm00356a005

Products guided by the article

Product name:4-methyl-5-(2-nitrophenyl)-1H-Imidazole

Cas No:75815-13-3

R&D Labs maybe for 75815-13-3

Shanghai Hope Chem Co., Ltd

website:http://www.hope-chem.com

Contact:86-21-58090396-805

Address:Floor 4, Building 5, No.588 Tianxiong Road, Zhoupu International Medical Zone, ShangHai, China
Shanghai Hope Chem Co., Ltd

website:http://www.hope-chem.com

Contact:86-21-58090396-805

Address:Floor 4, Building 5, No.588 Tianxiong Road, Zhoupu International Medical Zone, ShangHai, China
ShangHai Ruiyi Medical Technology Co.,Ltd.

Contact:+86-21-54718086

Address:No951 Jianchuan RD，Minhang District
Xiamen XM-Innovation Chemical Co., Ltd

Contact:+86-592-3216205

Address:Unit Q, 11/F, No.1 Office Building, Wuyuan Bay Business Center, Huli District, Xiamen City, Fujian Province, P.R.C
Shanghai Sharing technologies Co., Ltd.

Contact:86-021-66787223

Address:No11, Lane 225, Jinxiang Road,Pudong district

Relevant to this article

1-(4-Bromophenyl)-2-fluoroethanone (2,4-dinitrophenyl)hydrazone containing a particularly short fluorine-hydrogen bond

Doi:10.1107/S0108270196013133
(1997)
Doi:10.1016/0040-4020(67)85120-2
(1967)
Intra- and Intermolecular Nickel-Catalyzed Reductive Cross-Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides

Doi:10.1002/anie.201601206
(2016)
Reductive Hydroxymethylation of 4-Heteroarylpyridines

Doi:10.1002/chem.202000060
(2020)
Doi:10.1021/ja00844a063
(1975)
Synthesis of a biphenyl-based cyclophane via benzidine rearrangement of a constrained m-nitrophenol derivative

Doi:10.1016/S0040-4039(03)00343-5
(2003)

Article Doi