Journal of Medicinal Chemistry p. 140 - 144 (1983)
Update date:2022-08-02
Topics:
Hoffman
Pietruszkiewicz
Habecker
Phillips
Bolhofer
Cragoe Jr.
Torchiana
Lumma Jr.
Baldwin
Two series of compounds related to cimetidine and tiotidine were synthesized as part of a study to evaluate the importance of conformational parameters in binding at histamine H2 receptors. The flexible methylthioethyl connecting chain was repl
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