Nonsteroidal Antiinflammatory Agents. 2. Synthesis of 4',5-Disubstituted 3-Biphenylylacetic Acids and Their Derivatives with Antiinflammatory and Analgesic Activities

Article abstract of DOI:10.1021/jm00133a010

A series of 4',5-disubstituted 3-biphenylylacetic acids (5a-n) and several α-methyl derivatives (5o-v) were prepared as analogues of a newly developed nonsteroidal antiinflammatory agent, 4'-chloro-5-methoxy-3-biphenylylacetic acid <1 (DKA-9), R = 4-ClPh;