Journal of Organic Chemistry p. 771 - 775 (1981)
Update date:2022-08-04
Topics:
Howe, Robert K.
Shelton, Becky R.
1,3-Dipolar cycloadditions of aromatic nitrile sulfides to methyl o-cyanobenzoate and to phthalonitrile gave methyl 2-(3-aryl-1,2,4-thiadiazol-5-yl)benzoates 6a-c and 2-(3-phenyl-1,2,4-thiadiazol-5-yl)benzonitrile (7).Cycloaddition of 2-cyanobenzonitrile sulfide to aromatic nitriles gave 2-(5-aryl-1,2,4-thiadiazol-3-yl)benzonitriles 11a,b, which were converted to methyl 2-(5-aryl-1,2,4-thiadiazol-3-yl)benzoates 13a,b.Yields of the cycloadducts are increased by dilution of the reaction mixtures with a nonpolar solvent.
View MoreAUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD
Contact:+86-25-86883560 15951806178
Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.
Contact:86-513-84128750/13773795976
Address:No.48.Youyi West Road ,Rudong Development Zone,Jiangsu Province,China
Contact:86-21-58226973
Address:No 351,Guoshoujing Road, Zhangjiang Hi-tech Park, Pudong, Shanghai, China
website:http://www.shochem.com
Contact:021-50800795
Address:No.1043, Halei Rd, Zhangjiang Hi-Tech Park, Shanghai, Postcode 201203, China
website:http://www.guarson.com
Contact:+86-523-88059600,+86-13805268803
Address:Room B1006,Yafang Building,Jiangyan Avenue,Jiangyan District, Taizhou City,Jiangsu,China
Doi:10.1002/ardp.19522850502
(1952)Doi:10.1021/ja01473a002
(1961)Doi:10.1016/S0040-4039(00)77813-0
(1980)Doi:10.1021/jo00359a059
(1986)Doi:10.1055/s-1980-29175
(1980)Doi:10.1016/j.tetlet.2008.02.138
(2008)
