Journal of Organic Chemistry p. 1177 - 1182 (1981)
Update date:2022-08-05
Topics:
Hill, Alexander E.
Link, Daniel C.
Donndelinger Peter
(2,2-Dimethyl-4-penten-1-yl)magnesium bromide (1) is in equilibrium with its cyclic isomer, <(3,3-dimethylcyclobutyl)methyl>magnesium bromide (2).The equilibrium constant for this cyclization has a value of 2E-3.The gem-dimethyl substitution leads to an increase of a factor of about 22 in the equilibrium constant and also retards the rate of cleavage of 2.The sources of the gem-dimethyl effect in this system are discussed.
View Morezhengzhou Triz Pharma-Tech Co., Ltd
website:http://www.Trizpharma-tech.com
Contact:+86-0371-86597269，53392065
Address:High-tech Industrial Development Zone, Zhengzhou City, NO.7 Holly Street
Contact:86-510-82853889
Address:Rm.3732, No.18-2,Yonghe Rd.,Wuxi,Jiangsu,214023,China
Guangxi Bonger Pharmaceutical Co., Ltd
website:http://napo.lookchem.com/
Contact:+86-18817331185
Address:Donghai Industrial Zone, Tiandong Country,Guangxi,China
Shanghai Pengkai Chemical Co.,Ltd
Contact:+86-21-60526671
Address:No.4226 Duzhuang Rd Minhang District Shanghai China
Jiaxing Trustworthy Import And Export Co.,Ltd
Contact:+86-573-82030555
Address:Room 1202, Unit B, Charming plaza,No.1558 East Zhongshan Road , Jiaxing City, Zhejiang Province, China.
Doi:10.1021/ja01290a043
(1937)Doi:10.1021/jo00320a038
(1981)Doi:10.1016/0040-4020(82)80100-2
(1982)Doi:10.1021/ja00391a024
(1981)Doi:10.1248/cpb.31.4312
(1983)Doi:10.1021/ja047983a
(2004)
