Journal of Organic Chemistry p. 1177 - 1182 (1981)
Update date:2022-08-05
Topics:
Hill, Alexander E.
Link, Daniel C.
Donndelinger Peter
(2,2-Dimethyl-4-penten-1-yl)magnesium bromide (1) is in equilibrium with its cyclic isomer, <(3,3-dimethylcyclobutyl)methyl>magnesium bromide (2).The equilibrium constant for this cyclization has a value of 2E-3.The gem-dimethyl substitution leads to an increase of a factor of about 22 in the equilibrium constant and also retards the rate of cleavage of 2.The sources of the gem-dimethyl effect in this system are discussed.
View Morewebsite:http://www.antimex.com
Contact:0086-21-50563169
Address:Room1027,No.Jinyu Road,Pudong
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)
Contact:+86-21-54159691
Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100
Jiangsu Institute of Ecomones Co., Ltd
website:http://www.jsmone.com
Contact:+86-519-82821700
Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Nanjing Samwon International Limited
Contact:+86-25-84873444
Address:1108, BLDG B, New Century Plaza, No 1, South Taiping Rd.,
Angelisun(Chongqing) Pharmaceutical Co., LTD.
Contact:+86-23-68030926-816
Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
Doi:10.1021/ja01290a043
(1937)Doi:10.1021/jo00320a038
(1981)Doi:10.1016/0040-4020(82)80100-2
(1982)Doi:10.1021/ja00391a024
(1981)Doi:10.1248/cpb.31.4312
(1983)Doi:10.1021/ja047983a
(2004)
