Application of a new nucleophilic addition/ring closure (NARC) sequence to the synthesis of enantiomerically-pure 2,8-dioxabicyclo[3.2.1]octanes of relevance to the squalestatins and zaragozic acids

DOI: 10.1016/S0040-4039(99)01523-3

Source and publish data:

Tetrahedron Letters p. 7435 - 7438 (1999)

Update date:2022-08-04

Topics:

Authors:

Fallon, Gary D.

Jones, Eric D.

Perlmutter, Patrick

Selajarern, Walailak

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Article abstract of DOI:10.1016/S0040-4039(99)01523-3

A rapid method for the enantioselective construction of 2,8-dioxabicyclo[3.2.1]octanes of relevance to the zaragozic acids, employing a tandem NARC sequence of aldol and intramolecular Wacker reactions, is described.

Full text of DOI:10.1016/S0040-4039(99)01523-3

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