Amphipathic benzoic acid derivatives: Synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC

DOI: 10.1016/j.bmc.2007.01.044

Source and publish data:

Bioorganic and Medicinal Chemistry p. 2617 - 2623 (2007)

Update date:2022-09-26

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Authors:

Shin, Hyunshun

Gennadios, Heather A.

Whittington, Douglas A.

Christianson, David W.

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Article abstract of DOI:10.1016/j.bmc.2007.01.044

The first committed step in lipid A biosynthesis is catalyzed by uridine diphosphate-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase (LpxC), a zinc-dependent deacetylase, and inhibitors of LpxC may be useful in the development of antibacteria

Full text of DOI:10.1016/j.bmc.2007.01.044

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