Synthesis and Antitumor Evaluation of Some Nitrosourea and Nitrogen Mustard Amino Acid Derivatives

Article abstract of DOI:10.1021/jm00375a025

A series of (2-chloroethyl)nitrosourea and nitrogen mustard amino acid derivatives have been synthesized for antitumor evaluation.Reaction of an appropriate N-protected amino acid with 2-chloroethylamine followed by removal of the N-protecting group and c