The Synthesis and Transformation of Ethyl 2-(2-Acetyl-2-benzoyl-1-ethenyl)amino-3-dimethylaminopropenoate. A new Synthesis of 2,3,4-Trisubstituted Pyrroles

DOI: 10.1002/jhet.5570340619

Source and publish data:

Journal of Heterocyclic Chemistry p. 1757 - 1762 (1997)

Update date:2022-08-04

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Authors:

Malesic, Mateja

Krbavcic, Ales

Golobic, Amalija

Golic, Ljubo

Stanovnik, Branko

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Article abstract of DOI:10.1002/jhet.5570340619

The synthesis of ethyl 2-(2-acetyl-2-benzoyl-1-ethenyl)amino-3-dimethylaminopropenoate (4) from benzoylacetone (1) via 3-dimethylaminomethylenebenzoylacetone (2) and ethyl N-(2-acetyl-2-benzoyl-1-ethenyl)glycinate (3) and its transformation into 4-benzoyl-2-ethoxycarbonyl-3-methylpyrrole (9) is described. Cyclization of 4 into 9 represents a new synthesis of polysubstituted pyrroles.

Full text of DOI:10.1002/jhet.5570340619

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