PREPARATIONS OF 2-epi-FORTIMICINS A FROM 2-epi-FORTIMICIN B BY INTRAMOLECULAR BASE-CATALYZED 2-O-ACYLATION OF 1,2',6'-TRI-N-BENZYLOXYCARBONYL-2-EPI-FORTIMICIN B

Article abstract of DOI:10.1016/S0008-6215(00)80393-6

Preparation of 2-epi-fortimicin A (4) from 2-epi-fortimicin B (3) are described.In contrast to the previously reported, selective 4-N-acylation of 1,2',6'-tri-N-benzyloxycarbonylfortimicin B (8) with N-(N-benzyloxycarbonylglycyloxy)succinimide, 1,2',6'-tr