Carbon-carbon bond formation catalyzed by lithium perchlorate in dichloromethane

Article abstract of DOI:10.1016/S0040-4039(00)77505-8

A catalytic amount of lithium perchlorate suspended in dichloromethane provides a mild and effective medium for Mukaiyama aldol reactions of aldehydes with silyl ketene acetal (1). 2-Cyclohexenone undergoes clean 1,4-addition under similar conditions. Catalyst activity is much higher in dichloromethane than in diethyl ether.