Journal of Organic Chemistry p. 4425 - 4429 (1982)
Update date:2022-08-04
Topics:
Tashiro, Masashi
Yoshiya, Haruo
Fukata, Gouki
Treatment of 2,2'-dihydroxy-3,3',5,5'-tetra-tert-butylbiphenyl (3) with excess bromine in alcohols afforded the 2-alkoxy-1-bromo-4,6,8-tri-tert-butyldibenzofurans 6a,b in 68 percent and 44 percent yields, respectively.When compound 6a was treated with AlCl3 in boiling toluene, 2-hydroxydibenzofuran (14) was obtained in 79 percent yield together with bromotoluenes (15) and tert-butyltoluenes (10).However, at room temperature, this reaction afforded 1-bromo-2-methoxy-4-tert-butyldibenzofuran (16) in 74 percent yield.Futhermore, it was found that AlCl3-CH3NO2-catalyzed reaction of 6a in toluene gave 1-bromo-2-methoxy-4,6-di-tert-butyldibenzofuran (17) in 71 percent yield together with 10.From 6a were obtained 1,2,8-trihydroxy-(26) and 1,2,7,8-tetrahydroxydibenzofuran (27) in several steps.
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