Conversion of vinylsilanes to vinyl halides with xenon difluoride and metal halides. A versatile new route to 5-(2-halovinyl)pyrimidine nucleosides

DOI: 10.1016/S0040-4039(00)97919-X

Source and publish data:

Tetrahedron Letters p. 5633 - 5636 (1990)

Update date:2022-08-02

Topics:

Authors:

Robins Robins

Manfredini

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Article abstract of DOI:10.1016/S0040-4039(00)97919-X

Addition of a protected 5-(2-trimethylsilylvinyl)uracil nucleoside to suspensions of xenon difluoride and alkali metal halides in benzene (or other solvents) resulted in rapid formation of the corresponding 5-(2-halovinyl)uracil products (E-isomer predominating).

Full text of DOI:10.1016/S0040-4039(00)97919-X

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