Cyclic Urea Nucleosides. Cytidine Deaminase Activity as a Function of Aglycon Ring Size

DOI: 10.1021/jm00138a003

Source and publish data:

Journal of Medicinal Chemistry p. 662 - 666 (1981)

Update date:2022-08-04

Topics:

Authors:

Liu, Paul S.

Marquez, Victor E.

Driscoll, John S.

Fuller, Richard W.

McCormack, John J.

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Article abstract of DOI:10.1021/jm00138a003

Five β-D-ribofuranosyl cyclic urea nucleosides (14-18), ranging in size from five to eight membered, were synthesized and evaluated as cytidine deaminase (CDA) inhibitors.The precursor protected nucleosides (9-13) were prepared by a condensation procedure

Full text of DOI:10.1021/jm00138a003

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