Journal of the Chemical Society. Perkin transactions I p. 538 - 546 (1981)
Update date:2022-08-04
Topics:
Atherton, Eric
Logan, Christopher J.
Sheppard, Robert C.
Use of base-labile Nα-9-fluorenylmethoxycarbonylamino-acids in combination with acid-labile t-butyl or p-alkoxybenzyl side-chain or carboxy-terminal (resin-linkage) protecting groups enables solid-phase peptide synthesis to be carried out under exceptionally mild reaction conditions.The repetitive and vigorous acidic treatments required in conventional synthesis are avoided.High-yield syntheses of a decapeptide and of an undecapeptide amide (Substance P) are described using this new combination of protecting groups on polyamide supports.
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(1981)
